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The Belfer Legacy

In 1999, with generous support from the Arthur and Rochelle Belfer Foundation, the Belfer Center for Cancer Genomics was founded. The center initially focused on developing high-resolution platforms and computational tools for global genomic profiling of patterns of copy number aberrations in human cancers. The center established a robust pipeline for high-throughput genomic analyses of human and mouse tumors, and became one of The Cancer Genome Atlas’ select Cancer Genome Characterization Centers during its Pilot Phase (2006-2009).

In 2004, the Center for Applied Cancer Science at Dana-Farber Cancer Institute was established, designed to bring together the best attributes of academia and industry to rapidly translate cancer genomics knowledge into more effective cancer therapies. In 2006, with a visionary commitment from the Robert A. and Renee E. Belfer Foundation, the Belfer Center for Cancer Genomics and the Center for Applied Cancer Science became the Belfer Institute for Applied Cancer Science.

In the News

Poster presentation, PDx Platform of High Grade Serous Ovarian Cancer, at the 2014 AACR General Meeting in San Diego by Sangeetha Palakurthi PhD, Head of Cancer Biology and Pharmacology.

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Oral presentation, Serial monitoring of EGFR mutations in plasma NSCLC patients by ddPCR, at the 2014 AACR General Meeting in San Diego by Cloud Paweletz PhD, Head of Translational Research Lab.

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Findings from the Translational Research Lab within the Belfer Institute demonstrate that circulating DNA from non-invasive plasma samples is a promising biomarker to monitor response and predict resistance in the clinic.

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Belfer scientists collaborate with W. Kaelin MD , to demonstrate that the Ikaros family of transcription factors are key downstream mediators of the efficacy of thalidomide-like drugs.

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Pioneering study from the lab of Kwok Wong MD PhD, demonstrating that specific tumor mutations can drive immune escape, which has significant implications for the clinical development of immunomodulatory agents.

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